A focus on NKT cell subset characterization and developmental stages
نویسندگان
چکیده
منابع مشابه
Characterization of the early stages of thymic NKT cell development
Upon reaching the mature heat stable antigen (HSA)low thymic developmental stage, CD1d-restricted Valpha14-Jalpha18 thymocytes undergo a well-characterized sequence of expansion and differentiation steps that lead to the peripheral interleukin-4/interferon-gamma-producing NKT phenotype. However, their more immature HSAhigh precursors have remained elusive, and it has been difficult to determine...
متن کاملthe effects of multiple intelligences (focus on musical, visual, and linguistic) and direct instruction on learning grammar: a case on iranian efl students at elementary level
1.0 overview it seems that grammar plays a crucial role in the area of second and foreign language learning and widely has been acknowledged in grammar research. in other words, teaching grammar is an issue which has attracted much attention to itself, and a lot of teachers argue about the existence of grammar in language teaching and learning. this issue will remind us a famous sentence f...
A Critical Review of Kohlberg’s Theory of Moral Judgment and a Guideline on its Developmental Stages
A Critical Review of Kohlberg’s Theory of Moral Judgment and a Guideline on its Developmental Stages A.R. Assaareh, Ph.D. * A. Mahdizaadeh Tehraani** A.R. Amini Zarrin*** S. Azimi**** Developmental theories describe and explain stages in which different aspects of human psyche develop. Among such theories is Kohlberg’s theory of moral judgment wherein a complex ...
متن کاملIL-10-producing NKT10 cells are a distinct regulatory invariant NKT cell subset.
Invariant natural killer T (iNKT) cells rapidly produce copious amounts of multiple cytokines after activation, thereby impacting a wide variety of different immune reactions. However, strong activation of iNKT cells with α-galactosylceramide (αGalCer) reportedly induces a hyporeactive state that resembles anergy. In contrast, we determined here that iNKT cells from mice pretreated with αGalCer...
متن کاملNKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human.
IL-15 may have a role in the development of T cell large granular lymphocyte (T-LGL) or NKT leukemias. However, the mechanisms of action and the identity of the cell subset that undergoes leukemic transformation remain elusive. Here we show that in both mice and humans, NKp46 expression marks a minute population of WT NKT cells with higher activity and potency to become leukemic. Virtually 100%...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Immunology & Cell Biology
سال: 2020
ISSN: 0818-9641,1440-1711
DOI: 10.1111/imcb.12378